Enhancement of Human Lymphocyte Transformation by Aggregated Human Gamma Globulin

Human Gamma Globulin.

Cellular reaction to complexes formed between rheumatoid factor and aggregated human gamma globulin.

During the course of experiments to investigate whether the addition of heat-denatured 7S y-globulin to rheumatoid leucocytes would produce transformation of the lymphocytes, an interesting phenomenon was observed. No specific stimulation of the lymphocytes was seen, but intracellular inclusions in neutrophils and macrophages, accompanied by extracellular bodies, were noted after culture of the...

Structural units of human 7S gamma globulin.

Enhancement of mitogen-induced human lymphocyte transformation by diiron enneacarbonyl in serum-free medium.

Diiron enneacarbonyl, colloidal iron particles used for removing monocytes, enhanced the 3H-thymidine uptake into the mitogen-stimulated human lymphocytes in serum-free medium, whereas neither silica particles, latex particles, carbonyl iron powder nor iron pentacarbonyl did. Because monocytes had no influence on the enhancing effect or diiron enneacarbonyl did not bind to PHA, it was suggested...

Radioadaptive Response in Human Lymphocyte Cells

The adaptive response (AR) is a phenomenon by which cells exposure to sublethal doses of DNA-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (CT), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (CR). The adaptive response (AR) induced by radiation in human lymphocyte...